Flavonoids from the Roots of Campylotropis hirtella

Abstract

Eight new flavonoids, including three pterocarpene derivatives, hirtellanines C–E, two flavanones, hirtellanines F and G, three isoflavanones, hirtellanines H–J, as well as four known compounds were isolated from the roots of Campylotropis hirtella. The structures of the new compounds were elucidated by spectroscopic analyses, including 2D-NMR techniques. Pharmacological investigation indicated that the new compounds, particularly hirtellanines D and G, possessed potent immunosuppressive activities and low relative cytotoxicities.

Key words

Leguminosae - hirtellanines - roots of Campylotropis hirtella - flavonone - isoflavone - pterocarpene - immunosuppressive activities

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